| Subject: |
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Re: Beef Ultralente Insulin----The Gold Standard...a reminder |
| Name: |
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junkprincess |
| Date Posted: |
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Sep 27, 05 - 6:56 PM |
| IP Address: |
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12.73.236.50 |
| Email: |
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junkprincess@yahoo.com |
| Website: |
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http://www.postgradmed.com/issues/1997/02_97/white.htm |
| Message: |
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Although human ultralente is often used to mimic basal insulin secretion, its effects are not ideal. When given in subcutaneous doses of 0.4 U/kg in one study (13). human ultralente produced peak levels in excess of 60 microunits/mL within 5 hours of injection. Beef ultralente insulin given at the same dose had a time-concentration profile that more closely mimicked basal insulin secretion.
Seigler DE, Olsson GM, Agramonte RF, et al. Pharmacokinetics of long-acting (ultralente) insulin preparations. Diab Nutr Metab 1991;4:267-73
From the Indianapolis Star, December 1999
"Animal insulin is the Lindbergh of the space shuttle age," said Dr. John H. Holcombe, senior clinical research physician for diabetes care at Lilly. "It's antiquated."
So antiquated that a January 2005 study of Lantus referred to it, along with an insulin pumping study.
OFFW!
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