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Re: Re: John Holcombe of Lilly--In His Own Words!! |
| Name: |
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junkprincess |
| Date Posted: |
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Feb 22, 06 - 9:59 PM |
| IP Address: |
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68.165.41.209 |
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We have a collection of posts here featuring more of the WORST of John Holcombe--the original source URLs can be found at the original posts.
Holcombe and Lindbergh
Although human ultralente is often used to mimic basal insulin secretion, its effects are not ideal. When given in subcutaneous doses of 0.4 U/kg in one study (13). human ultralente produced peak levels in excess of 60 microunits/mL within 5 hours of injection. Beef ultralente insulin given at the same dose had a time-concentration profile that more closely mimicked basal insulin secretion.
Seigler DE, Olsson GM, Agramonte RF, et al. Pharmacokinetics of long-acting (ultralente) insulin preparations. Diab Nutr Metab 1991;4:267-73
From the Indianapolis Star, December 1999
"Animal insulin is the Lindbergh of the space shuttle age," said Dr. John H. Holcombe, senior clinical research physician for diabetes care at Lilly. "It's antiquated."
So antiquated that a January 2005 study of Lantus referred to it, along with an insulin pumping study.
He "forgot", apparently that the Space Shuttle is of little use when planning a busines or vacation trip.....
Holcombe "Betrayed"
1998
Iletin® II (pork) insulin will remain available as will the newer human insulins. Animal insulins account for only 6 to 7 percent of the 3.2 million U.S. insulin users, says Dr. John Holcombe, Lilly's senior clinical research physician. He says that Lilly is planning to discontinue Iletin® I to narrow the company's product range.
"We didn't think it would be proper to put such a specific product announcement on the Web site," he says. "We wanted to go to physicians first, but the information is already out there."
Dr. Holcombe blames Diabetes Interview Publisher Scott King for telling consumers about Lilly's plans. "Our communications strategy has been torpedoed midship," he says. "We asked Scott to keep certain information we gave him in confidence. We felt a little betrayed by that."
Nowhere nearly as betrayed as natural insulin users have been by Eli Lilly.
It Does NOT Cause Hypos--Because I Said So
Diabetic Lifestyle March 1999
John Holcombe, MD, a senior clinical physician at Lilly says that current research shows that switching to human-based insulin does not cause hypoglycemia unawareness.
No elaboration on whose reasearch, when, where, published findings.....
Holcombe & Lindbergh 2--You're Not Trying Hard Enough!
From the Indianapolis Star, December 1999
"Animal insulin is the Lindbergh of the space shuttle age," said Dr. John H. Holcombe, senior clinical research physician for diabetes care at Lilly. "It's antiquated."
Holcombe, the Lilly physician, said analysis of those calls convinces him that most people who have problems switching from animal to human insulin haven't tried hard enough to get used to it, or lack guidance on tailoring doses to their bodies and lifestyles.
"We don't know of a single case where a patient has not been successfully transferred working with a doctor," he said.
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