Return to Website

Reply

Home

Subject:   Re: Insulin for Heart Attacks?? Name:   Claudia Date Posted:   Sep 7, 06 - 10:20 AM IP Address:   70.127.203.48 Email:   cfrench180@tampabay.rr.com Website:   http://www.magnesiumforlife.com/ Message:   In contrast see: the benefits of magnesium administration have been shown in a variety of cardiovascular diseases.4-7 In the setting of coronary artery disease, several studies have shown the efficacy of magnesium infusion in patients with acute myocardial infarction,4 vasospastic angina,5 and unstable angina.8 While several mechanisms are probably responsible for the favourable effects of magnesium, the coronary vasodilatory effect seems to be the primary mechanism responsible for the beneficial effects of magnesium.9-11 However, only a few studies have investigated human coronary responses to magnesium infusion in vivo CONCLUSIONS: Magnesium dilates both the epicardial and resistance coronary arteries in humans. Furthermore, the coronary arterial response to magnesium is dose dependent and independent of EDNO. http://heart.bmjjournals.com/cgi/content/full/86/2/212 We have recently demonstrated that oral magnesium treatment can improve endothelium-dependent vasodilation in CAD patients with optimal lipid values. Because nitric oxide is a potent endogenous vasodilator and inhibitor of platelet aggregation and adhesion, hypomagnesemia could promote vasoconstriction and coronary thrombosis in hypomagnesemic states. These findings suggest a potential mechanism whereby magnesium may beneficially alter outcomes in CAD patients. http://www.ncbi.nlm.nih.gov/entrez/query.fcgiitool=abstractplus&db=pubmed&cmd=Retrieve&dopt=abstractplus&list_uids=11105330 Although some previous relatively small randomized clinical trials demonstrated a remarkable reduction in mortality when intravenous magnesium was administered to relatively high risk AMI patients, two recently published large-scale randomized clinical trials (the Fourth International Study of Infarct Survival [ISIS 4] and Magnesium in Coronaries [MAGIC]) were unable to demonstrate any advantage of intravenous magnesium over placebo. Nevertheless, the theoretical benefits of magnesium supplementation as a cardio-protective agent in CAD patients, promising results from animal and human studies, its relatively low-cost and ease of handling requiring no special expertise, together with its excellent tolerability, gives magnesium a place in treating CAD patients, especially in those at high risk, such as CAD patients with heart failure, the elderly and hospitalized patients with hypomagnesemia. Furthermore, magnesium therapy is indicated in life-threatening ventricular arrhythmias such as torsades de pointes and intractable ventricular tachycardia. Am J Cardiovasc Drugs. 2003;3(4):231-9. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?itool=abstractplus&db=pubmed&cmd=Retrieve&dopt=abstractplus&list_uids=14728075 Also in Clin Calcium. 2005 Nov;15(11):111-5 Can't help but wonder if the dose dependency was the issue with the findings of the ISIS study? Numerous studies have suggested that magnesium ion (Mg(2+)) plays an important role in pathogenesis of cardiovascular diseases including hypertension, ischemic heart disease. Hypomagnesemia is often associated with the imbalance of sodium, potassium, and calcium ions. Magnesium deficiency can occur frequently in alcoholics, and in patients with hypertension, congestive heart failure, myocardial infarction. Magnesium deficiency induces an increase in intracellular Ca(2+) concentration in cardiac myocytes, formation of reactive oxygen species, production of inflammatory cytokines, leading to the development of ischemic heart disease, congestive heart disease, sudden cardiac death, atherosclerosis, and arrhythmia. In addition, catecholamines can evoke marked Mg(2+)efflux which is associated with a concomitant increase in the force of contraction of the heart. While many of the mechanisms remains elusive, the beneficial effects of magnesium on the myocardium appear to be convincing. Further studies will be necessary to elucidate the molecular basis of the cardio-protective effects of magnesium Clin Calcium. 2005 Nov;15(11):77-83. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16272616&itool=iconabstr&query_hl=6&itool=pubmed_docsum Please learn about magnesium and its trememdous benefits to all people and to diabetics at: http://www.magnesiumforlife.com/

Reply

Home